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  • Pregnancy Outcomes in Association with STDs including genital HSV-2 shedding in a South African Cohort Study.

    Posted 2018-01-16 11:00:20 by: Mahammad A. Tafida

    Related Articles Pregnancy Outcomes in Association with STDs including genital HSV-2 shedding in a South African Cohort Study. Sex Transm Infect. 2017 Nov;93(7):460-466 Authors: Moodley D, Sartorius B, Madurai S, Chetty V, Maman S Abstract OBJECTIVES: Genital herpes simplex virus-2 (HSV-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes. METHODS: In this retrospective observational study, we included a subgroup of pregnant women who were enrolled in a randomized control behavioural intervention study that was conducted in South Africa in 2008-2010. In pregnancy, women had a HIV rapid test done and a genital swab taken to test for curable STIs and HSV-2 DNA. Subsequent visits were scheduled for 6, 10, 14 weeks and 9 months post-delivery. Pregnancy outcomes were documented at the 6-week or 10-week postpartum visit. Women were treated syndromically for curable STIs. RESULTS: Among 615 women included in this data analysis, 36.6% (n=225) tested HIV positive and 8.3% (n=51) tested positive for genital HSV-2 shedding during pregnancy. Women <24 years and HIV-1 seropositive women were 1.5 and 2.5 times more likely to test positive for HSV-2 genital shedding respectively. STI treatment records were available for 158/205 (77.1%) women; all 87 women with symptomatic STIs were treated the same day, and 50/71 (70.4%) asymptomatic women received treatment at the subsequent visit. Remaining 21 (29.6%) asymptomatic women did not receive treatment because they failed to return for antenatal follow-up. In a multivariable regression analysis, genital HSV-2 shedding, HIV-1, Neisseria gonorrhoea, Chlamydia trachomatis and Trichomanas vaginalis were not associated with preterm deliveries, still births and low birth weight. However with stratification by treatment for a STI, asymptomatic women ...

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  • Neisseria gonorrhoeae DNA bacterial load in men with symptomatic and asymptomatic gonococcal urethritis.

    Posted 2018-01-16 11:00:20 by: Mahammad A. Tafida

    Related Articles Neisseria gonorrhoeae DNA bacterial load in men with symptomatic and asymptomatic gonococcal urethritis. Sex Transm Infect. 2017 Nov;93(7):478-481 Authors: Priest D, Ong JJ, Chow EPF, Tabrizi S, Phillips S, Bissessor M, Fairley CK, Bradshaw CS, Read TRH, Garland S, Chen M Abstract OBJECTIVE: Previous studies have quantified bacterial loads of Neisseria gonorrhoeae in the pharynx and rectum of men but not the urethra. We quantified the bacterial load of N. gonorrhoeae in men with symptomatic and asymptomatic urethral gonorrhoea infections. METHODS: Consecutive men diagnosed with urethral gonorrhoea by Aptima Combo 2 testing of urine at the Melbourne Sexual Health Centre between March and July 2016 were eligible for the study: symptomatic men with purulent urethral discharge and asymptomatic men with no urethral symptoms. The gonococcal bacterial load in both groups was measured by urethral swab using a standardised collection method and real-time quantitative PCR targeting the opa gene. RESULTS: Twenty men were recruited into the study: 16 had purulent urethral discharge and 4 had asymptomatic urethral gonorrhoea. The median gonococcal bacterial load was significantly higher among symptomatic men (3.7×106 copies per swab, IQR 2.5×106-4.7×106) compared with asymptomatic men (2.0×105 copies per swab, IQR 2.7×104-4.5×105) (p=0.002). CONCLUSIONS: Gonococcal loads in men with urethral discharge were higher than loads seen with asymptomatic urethral gonorrhoea and loads seen in asymptomatic pharyngeal and rectal gonorrhoea infections in previous studies. PMID: 28148678 [PubMed - indexed for ...

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  • An integrative approach to predicting the functional effects of small indels in non-coding regions of the human genome.

    Posted 2018-01-16 11:00:20 by: Mahammad A. Tafida

    Related Articles An integrative approach to predicting the functional effects of small indels in non-coding regions of the human genome. BMC Bioinformatics. 2017 Oct 06;18(1):442 Authors: Ferlaino M, Rogers MF, Shihab HA, Mort M, Cooper DN, Gaunt TR, Campbell C Abstract BACKGROUND: Small insertions and deletions (indels) have a significant influence in human disease and, in terms of frequency, they are second only to single nucleotide variants as pathogenic mutations. As the majority of mutations associated with complex traits are located outside the exome, it is crucial to investigate the potential pathogenic impact of indels in non-coding regions of the human genome. RESULTS: We present FATHMM-indel, an integrative approach to predict the functional effect, pathogenic or neutral, of indels in non-coding regions of the human genome. Our method exploits various genomic annotations in addition to sequence data. When validated on benchmark data, FATHMM-indel significantly outperforms CADD and GAVIN, state of the art models in assessing the pathogenic impact of non-coding variants. FATHMM-indel is available via a web server at indels.biocompute.org.uk. CONCLUSIONS: FATHMM-indel can accurately predict the functional impact and prioritise small indels throughout the whole non-coding genome. PMID: 28985712 [PubMed - indexed for ...

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  • The paradox of public holidays: Hospital-treated self-harm and associated factors.

    Posted 2018-01-16 11:00:20 by: Mahammad A. Tafida

    Related Articles The paradox of public holidays: Hospital-treated self-harm and associated factors. J Affect Disord. 2017 Aug 15;218:30-34 Authors: Griffin E, Dillon CB, O'Regan G, Corcoran P, Perry IJ, Arensman E Abstract BACKGROUND: Recent research on the patterns of self-harm around public holidays is lacking. This study used national data to examine the patterns of hospital-treated self-harm during public holidays, and to examine associated factors. METHODS: Data on self-harm presentations to all emergency departments were obtained from the National Self-Harm Registry Ireland. The association between self-harm presentations and public holidays was examined using univariate and multivariate Poisson regression analyses. RESULTS: A total of 104,371 presentations of self-harm were recorded between 2007 and 2015. The mean number of self-harm presentations was 32 on public holidays. St. Patrick's Day had the highest number of presentations compared to all other public holidays, with a daily mean of 44 presentations. Across all years, self-harm presentations during public holidays had a 24% increased risk of involving alcohol consumption compared to all other days and this effect was most pronounced during the Christmas period. The association with alcohol remained significant at a multivariate level. Presentations on public holidays were more likely to attend out of normal working hours. An increase in male presentations involving self-cutting was observed on public holidays and there was an over-representation of males presenting for the first time. LIMITATIONS: It is likely that extent of alcohol involvement in self-harm presentations reported here is an underestimate, as it was dependent on the information being recorded by the attending clinician. CONCLUSIONS: Public holidays are associated with an elevated number of self-harm presentations to hospital, with presentations to ...

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  • obstetrics gynaecology AND ("last 5 years"[PDat] AND Humans[Mesh]); +43 new citations

    Posted 2018-01-13 23:00:15 by: Mahammad A. Tafida

    43 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: obstetrics gynaecology AND ("last 5 years"[PDat] AND Humans[Mesh]) These pubmed results were generated on 2018/01/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web ...

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  • obstetrics gynaecology AND ("last 5 years"[PDat] AND Humans[Mesh]); +43 new citations

    Posted 2018-01-13 11:00:19 by: Mahammad A. Tafida

    43 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: obstetrics gynaecology AND ("last 5 years"[PDat] AND Humans[Mesh]) These pubmed results were generated on 2018/01/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web ...

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  • Ovarian surgery for symptom relief in women with polycystic ovary syndrome.

    Posted 2018-01-11 11:00:31 by: Mahammad A. Tafida

    Related Articles Ovarian surgery for symptom relief in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2017 11 10;11:CD009526 Authors: Lepine S, Jo J, Metwally M, Cheong YC Abstract BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine condition, affecting approximately one in 10 women. PCOS is defined by two of three features: oligo- or anovulation, clinical or biochemical hyperandrogenism or both, or polycystic ovaries.Women with PCOS can have a wide range of health problems, including infrequent and irregular periods, unwanted hair growth and acne, and subnormal fertility. Long-term health concerns include an increased risk of heart disease, diabetes and the development of precancerous disease of the womb. OBJECTIVES: To assess the effectiveness and harms of ovarian surgery as a treatment for symptomatic relief of hirsutism, acne and menstrual irregularity in PCOS. SEARCH METHODS: We searched the Cochrane Gynaecology and Fertility Group specialized register, CENTRAL, MEDLINE, Embase and PsycINFO (from inception to 17 October 2016). We handsearched citation lists, registers of ongoing trials and conference proceedings. SELECTION CRITERIA: We included randomized controlled trials (RCTs) of women undergoing ovarian drilling in comparison to no treatment, medical treatment, or other forms of surgical treatment for the symptoms of PCOS. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures recommended by Cochrane. The primary outcome measures were improvement in menstrual regularity and androgenic symptoms of PCOS (hirsutism, acne); the secondary outcome measures included harms, change of body mass index (BMI), waist circumference, androgen levels, metabolic measures and quality of life. We assessed the quality of the evidence using GRADE methods. MAIN RESULTS: We included 22 RCTs (2278 women analyzed) of participants with ...

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