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  • infectious disease AND ("last 5 years"[PDat] AND Animals[Mesh:noexp]); +31 new citations

    Posted 2017-12-13 11:00:06 by: Mahammad A. Tafida

    31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: infectious disease AND ("last 5 years"[PDat] AND Animals[Mesh:noexp]) These pubmed results were generated on 2017/12/13PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web ...

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  • infectious disease AND ("last 5 years"[PDat] AND Animals[Mesh:noexp]); +45 new citations

    Posted 2017-12-12 23:00:07 by: Mahammad A. Tafida

    45 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: infectious disease AND ("last 5 years"[PDat] AND Animals[Mesh:noexp]) These pubmed results were generated on 2017/12/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web ...

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  • infectious disease AND ("last 5 years"[PDat] AND Animals[Mesh:noexp]); +45 new citations

    Posted 2017-12-12 11:00:13 by: Mahammad A. Tafida

    45 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: infectious disease AND ("last 5 years"[PDat] AND Animals[Mesh:noexp]) These pubmed results were generated on 2017/12/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web ...

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  • Bartha-k61 vaccine protects growing pigs against challenge with an emerging variant pseudorabies virus.

    Posted 2017-12-09 23:00:28 by: Mahammad A. Tafida

    Related Articles Bartha-k61 vaccine protects growing pigs against challenge with an emerging variant pseudorabies virus. Vaccine. 2017 Feb 22;35(8):1161-1166 Authors: Zhou J, Li S, Wang X, Zou M, Gao S Abstract Since late 2011, pseudorabies (PR) has resurfaced in many large pig farms, causing great economic loss for the swine industry in China. The PRV variant strain with high virulence and antigenic variation has been considered to be the main cause, and much attention has been focused on how to prevent and control the reoccurrence of this disease in China. In this study, two kinds of vaccination strategy were employed to evaluate the protective effects of Bartha-k61vaccine against both variant PRV (XJ5) and classical PRV (Ra) strain challenge. Humoral immunity response, clinical signs, survival rate, body weight, virus shedding and pathology were assessed in commercial pigs. The results showed that Bartha-k61vaccine, administered either once or twice, was effective against the PRV variant (XJ5) challenge, while no significant differences were observed between single and prime-boost vaccinated pigs. However, pigs vaccinated twice had better body weight gains than those vaccinated once, following challenge with the classical PRV strain (Ra) (p<0.01). Therefore, the Bartha-k61 vaccine appears to be an effective vaccine to control the spread of PRV variants in China in the absence of new powerful candidate vaccines specific to these PRV strains. PMID: 28131396 [PubMed - indexed for ...

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  • Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep.

    Posted 2017-12-09 23:00:28 by: Mahammad A. Tafida

    Related Articles Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep. Ecol Lett. 2017 10;20(10):1325-1336 Authors: Plowright RK, Manlove KR, Besser TE, Páez DJ, Andrews KR, Matthews PE, Waits LP, Hudson PJ, Cassirer EF Abstract Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free-ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age-structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation. PMID: 28871636 [PubMed - indexed for ...

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  • An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers.

    Posted 2017-12-09 23:00:28 by: Mahammad A. Tafida

    Related Articles An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers. Vaccine. 2017 Feb 22;35(8):1175-1183 Authors: Wijaya L, Tham CYL, Chan YFZ, Wong AWL, Li LT, Wang LF, Bertoletti A, Low JG Abstract BACKGROUND: Rabies is a fatal disease where post-exposure prophylaxis (PEP) is crucial in preventing infection. However, deaths even after appropriate PEP, have been reported. The PIKA Rabies vaccine adjuvant is a TLR3 agonist that activates B and T cells leading to a robust immune response. METHODS: We conducted a phase I, open label, randomized study in healthy adults to assess the safety and immunogenicity of the PIKA Rabies vaccine and an accelerated vaccine regimen. Thirty-seven subjects were randomized into 3 groups: control vaccine classic regimen, PIKA vaccine classic regimen and PIKA vaccine accelerated regimen. Subjects were followed up for safety, rabies virus neutralizing antibodies (RVNA) and T cell responses. RESULTS: Both the control and PIKA Rabies vaccine were well tolerated. All adverse events (AEs) were mild and self-limiting. Seventy-five percent of subjects in the PIKA accelerated regimen achieved a RVNA titer ⩾0.5IU/mL on day 7, compared to 53.9% in the PIKA classic regimen (p=0.411) and 16.7% in control vaccine classic regimen (p=0.012). The PIKA rabies vaccine elicited multi-specific rabies CD4 mediated T cell response already detectable ex vivo at day 7 after vaccination and that was maintained at day 42. CONCLUSION: The investigational PIKA rabies vaccine was well tolerated and more immunogenic than the commercially available vaccine in healthy adults. Clinical trial registry: The study was registered with clinicaltrials.gov NCT02657161. PMID: 28118938 [PubMed - indexed for ...

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  • Resistance, tolerance and environmental transmission dynamics determine host extinction risk in a load-dependent amphibian disease.

    Posted 2017-12-09 23:00:28 by: Mahammad A. Tafida

    Related Articles Resistance, tolerance and environmental transmission dynamics determine host extinction risk in a load-dependent amphibian disease. Ecol Lett. 2017 09;20(9):1169-1181 Authors: Wilber MQ, Knapp RA, Toothman M, Briggs CJ Abstract While disease-induced extinction is generally considered rare, a number of recently emerging infectious diseases with load-dependent pathology have led to extinction in wildlife populations. Transmission is a critical factor affecting disease-induced extinction, but the relative importance of transmission compared to load-dependent host resistance and tolerance is currently unknown. Using a combination of models and experiments on an amphibian species suffering extirpations from the fungal pathogen Batrachochytrium dendrobatidis (Bd), we show that while transmission from an environmental Bd reservoir increased the ability of Bd to invade an amphibian population and the extinction risk of that population, Bd-induced extinction dynamics were far more sensitive to host resistance and tolerance than to Bd transmission. We demonstrate that this is a general result for load-dependent pathogens, where non-linear resistance and tolerance functions can interact such that small changes in these functions lead to drastic changes in extinction dynamics. PMID: 28745026 [PubMed - indexed for ...

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