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  • [Correspondence] Laminar flow: the better choice in orthopaedic implants – Authors' reply

    Posted 2017-07-01 00:00:00 dun: Mahammad A. Tafida

    We appreciate Paul Jutte and colleagues' comments on our systematic review of studies of the effect of laminar airflow ventilation on surgical site infections (SSI).1 One of their main concerns is the use of data obtained from national surveillance systems and registries, since these databases were not designed specifically to address whether laminar airflow systems decrease the risk of SSIs. In their comment, Weinstein and Bonten2 also highlighted the high amount of clinical and statistical heterogeneity of the studies included in our ...

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  • [Newsdesk] Incarceration and infection: drug policy in the USA

    Posted 2017-07-01 00:00:00 dun: Mahammad A. Tafida

    The USA is in the midst of an opiate addiction crisis. Resurrecting the war on drugs will only serve to harm public health and risks spreading infections. Talha Burki ...

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  • [Clinical Picture] Neisseria meningitidis subdural empyema causing acute cauda equina syndrome

    Posted 2017-07-01 00:00:00 dun: Mahammad A. Tafida

    A 22-year-old man presented to a hospital emergency department with symptoms of bacterial meningitis but without focal neurology. Blood and CSF cultures were positive for Neisseria meningitidis serogroup B. He received empirical bacterial meningitis therapy on presentation to the hospital as per local guidelines with 4 g ceftriaxone every 24 h, vancomycin titrated to >20 mg/L and 10 mg dexamethasone every 6 h, and 1·8 g benzylpenicillin every 4 h. On day 2 after admission, after bacterial identification of N meningitidis, treatment was simplified to the use of high dose ceftriaxone ...

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  • [Comment] Improving communication about viral hepatitis in Africa

    Posted 2017-07-01 00:00:00 dun: Mahammad A. Tafida

    Viral hepatitis is the seventh leading cause of death worldwide.1 By 2030, WHO's elimination strategy2 seeks to reduce mortality from chronic infection with hepatitis B and C viruses by 65%. To achieve this goal, it is essential to scale up antiviral treatment programmes in low-income and middle-income countries, where most deaths due to hepatitis occur. These programmes must identify, engage, and retain infected populations. Yet, only with a genuine understanding of viral hepatitis can people living with these infections fully commit to a treatment ...

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  • [Correspondence] How artificial is the antibiotic resistance definition?

    Posted 2017-07-01 00:00:00 dun: Mahammad A. Tafida

    Streptococcus pneumoniae is naturally susceptible to β-lactams since no β-lactamases have been described in this bacterium.1 Penicillin and cefotaxime, the preferred antibiotics for treating pneumococcal infections, act in the same way on S pneumoniae by inhibiting the peptidoglycan assembly.1 Thus, biologically, there should be no pneumococcus resistant to cefotaxime and resistant to penicillin. However, defining the minimum inhibitory concentrations (MICs) that indicate whether a bacterium is susceptible, intermediate, or resistant to antibiotics is a complex issue that depends on the microorganism, patient, and antibiotic ...

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