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Obstetrics and gynecology
  • Giant fetal hydrometrocolpos associated with cloacal anomaly causing postnatal respiratory distress.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles Giant fetal hydrometrocolpos associated with cloacal anomaly causing postnatal respiratory distress. J Obstet Gynaecol Res. 2017 Nov;43(11):1769-1772 Authors: Kanda T, Iizuka T, Yamazaki R, Iwadare J, Ono M, Fujiwara H Abstract Persistent cloaca is a rare presentation wherein the urethra, vagina, and rectum converge into a common channel with a single perineal opening. Fetal hydrometrocolpos can result if fluid accumulates behind an obstruction of this common channel. A 29-year-old woman (G4P1021) was referred at 36 2/7 weeks of gestation for evaluation of a fetal abdominal cystic mass. Detailed ultrasonography and magnetic resonance imaging showed two symmetric cystic masses, bilateral hydronephrosis, and oligohydramnios. Elective cesarean delivery was performed at 37 0/7 weeks; the baby weighed 4043 g with Apgar scores of 5 and 6 at 1 and 5 min. Intubation was performed for respiratory distress, and the infant was noted to have an imperforate anus; persistent cloaca was diagnosed. Drainage of the hydrometrocolpos improved the infant's breathing remarkably, and extubation was achieved. This child's imaging findings are among the largest ever reported, and resulted in neonatal respiratory distress. PMID: 28707775 [PubMed - indexed for ...

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  • Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas. In Vivo. 2017 Nov-Dec;31(6):1229-1234 Authors: Tsekouras A, Mantas D, Tsilimigras DI, Moris D, Kontos M, Zografos GC Abstract BACKGROUND: Adipose tissue contains variable amounts of stem cells that have recently attracted increased interest due to their strong proliferative and differentiation capacity. However, significant heterogeneity exists in terms of stem cell yield and viability profile among individuals as well as different donor areas. MATERIALS AND METHODS: Between June 2016 and July 2016, forty (40) women underwent outpatient cosmetic liposuction procedures conferring a total of 53 lipoaspirates; inner thigh (n=13), outer thigh (n=9), abdomen (n=9), waist (n=16) and inner knee (n=6). Lipoaspirates were harvested using a tulip low-pressure syringe lipoaspiration system with a diameter of 3 mm. Centrifugation separated adipocytes from the stromal vascular fraction (SVF). Isolation of the adipose-derived stem cells (ASCs) was achieved through culture of the SVF. Viability of SVF cells and ASCs was evaluated with trypan blue dye under microscope and using flow cytometry with 7-AAD staining, respectively. Total cell count was estimated for both the SVF and ASCs. RESULTS: Outer thigh exhibited significantly higher SVF cell count compared to any other donor site (p<0.05). In addition, inner and outer thigh showed a significantly higher number of ASCs compared to abdominal, waist, and inner knee samples (p<0.05). Finally, viability of SVF cells (range, 94-95%) and ASCs (range, 93.12-96.14%) was excellent with no significant differences among donor areas. CONCLUSION: Tissue-harvesting area is a strong determinant of the quality of the fat grafts. Compared to abdomen, waist and inner knee, thighs seem favorable in terms of viability profile and yield of SVF cells ...

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  • Macrosomia Rates in Women with Diet-Controlled Gestational Diabetes: A Retrospective Study.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles Macrosomia Rates in Women with Diet-Controlled Gestational Diabetes: A Retrospective Study. J Pregnancy. 2017;2017:4935397 Authors: Vally F, Presneill J, Cade T Abstract BACKGROUND: Current data on the rates of macrosomia in women with gestational diabetes mellitus (GDM) are heterogenous. No study has specifically examined macrosomia rates in women with diet-controlled gestational diabetes. AIMS: To compare the rates of macrosomia between mothers with diet-controlled GDM to mothers without diabetes mellitus. METHODS: A retrospective study in which all patients with diet-controlled GDM and singleton pregnancies in 2014 were considered for inclusion in the study. These cases were individually matched to mothers without GDM and without type 1 or 2 diabetes. Cases were matched to parity, age, and BMI. Controls were selected from the same year and as close as possible to the date of delivery of the case. Primary outcomes were macrosomia, defined by estimated fetal weight >90th centile and >95th centile (separately). RESULTS: The estimated adjusted odds ratio for the presence of maternal GDM in the presence of EFW > 90th percentile (adjusted for maternal age, BMI, gravidity, parity, baby gender, and EGA) was 0.63 (95% CI 0.30-1.3; P = 0.21). The estimated adjusted odds ratio for the association of maternal GDM and EFW > 95th percentile was 0.66 (95% CI 0.26-1.7; P = 0.38). CONCLUSIONS: Our findings suggest that macrosomia is not increased in women with diet-controlled GDM. The study registration number is AQA 16/01. PMID: 28928985 [PubMed - indexed for ...

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  • Relationship between user satisfaction with the levonorgestrel-releasing intrauterine system and bleeding patterns.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles Relationship between user satisfaction with the levonorgestrel-releasing intrauterine system and bleeding patterns. J Obstet Gynaecol Res. 2017 Nov;43(11):1732-1737 Authors: Carvalho NM, Chou V, Modesto W, Margatho D, Garcia EAL, Bahamondes L Abstract AIM: Satisfaction with a contraceptive method constitutes an important factor in its acceptance and long-term use. The objective of this study was to assess the relationship between user satisfaction with the 20-μg/day levonorgestrel-releasing intrauterine system (LNG-IUS) and the bleeding patterns reported at two different time-points during follow-up. METHODS: A total of 251 LNG-IUS users aged 18-45 years were invited to answer a questionnaire on their return to the clinic for a routine follow-up visit and again 1 year later. Data were collected face-to-face. RESULTS: Twenty women discontinued prematurely; therefore, the analysis was performed on 231 women. Most users were either highly satisfied (66.6% and 66.2% at the first and second interviews, respectively) or satisfied (26.4% and 26.4% at the first and second interviews, respectively) with the LNG-IUS. Satisfaction was related to amenorrhea (P < 0.001) and duration of use (P < 0.001). Prolonged bleeding and spotting were the main causes of dissatisfaction with the device. CONCLUSION: Most LNG-IUS users in this sample were satisfied with the device. The only two factors associated with satisfaction were amenorrhea and duration of use, while prolonged bleeding and spotting were the main causes of dissatisfaction. These findings could be useful for health-care professionals and policy-makers when developing information material for women. The study provides insight into the profile of satisfied LNG-IUS users; however, this information is not suitable for counseling women who are considering using an LNG-IUS. PMID: 28833891 [PubMed - indexed for ...

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  • A cross-sectional study estimating the burden of illness related to genital warts in South Korea.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles A cross-sectional study estimating the burden of illness related to genital warts in South Korea. BMJ Open. 2017 Jul 02;7(6):e014217 Authors: Lee TS, Kothari-Talwar S, Singhal PK, Yee K, Kulkarni A, Lara N, Roset M, Giuliano AR, Garland SM, Ju W Abstract OBJECTIVES: Estimate the prevalence of genital warts (GW) and GW-related healthcare resource use and costs among male and female patients seeking treatment in South Korea. DESIGN: To estimate GW prevalence, physicians in five major South Korean regions recorded daily logs of patients (n=71 655) seeking care between July 26 and September 27, 2011. Overall prevalence estimates (and 95% CIs) were weighted by the estimated number of physicians in each specialty and the estimated proportion of total patients visiting each specialist type. Healthcare resource use was compared among different specialties. Corresponding p values were calculated using Mann-Whitney U tests. SETTING: The database covers 5098 clinics and hospitals for five major regions in South Korea: Seoul, Busan, Daegu, Gwangju and Daejeon. PARTICIPANTS: Primary care physicians (general practice/family medicine), obstetricians/gynaecologists, urologists and dermatologists with 2-30 years' experience. RESULTS: The estimated overall GW prevalence was 0.7% (95% CI 0.7% to 0.8%). Among women, GW prevalence was 0.6% (95% CI 0.6% to 0.7%); among men prevalence was 1.0% (95% CI 0.9% to 1.0%), peaking among patients aged 18-24 years. Median costs for GW diagnosis and treatment for male patients were US$58.2 (South Korean Won (KRW) ₩66 857) and US$66.3 (KRW₩76 113) for female patients. CONCLUSIONS: The estimated overall GW prevalence in South Korea was 0.7% and was higher for male patients. The overall median costs associated with a GW episode were higher for female patients than for male patients. PMID: 28674130 [PubMed - indexed for ...

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  • Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles Tracking the Impact of Excisional Cervical Treatment on the Cervix using Biospectroscopy. Sci Rep. 2016 12 15;6:38921 Authors: Halliwell DE, Kyrgiou M, Mitra A, Kalliala I, Paraskevaidis E, Theophilou G, Martin-Hirsch PL, Martin FL Abstract Local excisional treatment for cervical intra-epithelial neoplasia (CIN) is linked to significant adverse sequelae including preterm birth, with cone depth and radicality of treatment correlating to the frequency and severity of adverse events. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy can detect underlying cervical disease more accurately than conventional cytology. The chemical profile of cells pre- and post-treatment may differ as a result of altered biochemical processes due to excision, or treatment of the disease. Since pre-treatment cervical length varies amongst women, the percentage of cervix excised may correlate more accurately to risk than absolute dimensions. We show that treatment for CIN significantly alters the biochemistry of the cervix, compared with women who have not had treatment; this is due to the removal of cervical tissue rather than the removal of the disease. However, the spectra do not seem to correlate to the cone depth or proportion of cervical length excised. Future research should aim to explore the impact of treatment in a larger cohort. PMID: 27974821 [PubMed - indexed for ...

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  • Novel population of small tumour-initiating stem cells in the ovaries of women with borderline ovarian cancer.

    Posted 2018-06-16 10:00:54 by: Mahammad A. Tafida

    Related Articles Novel population of small tumour-initiating stem cells in the ovaries of women with borderline ovarian cancer. Sci Rep. 2016 10 05;6:34730 Authors: Virant-Klun I, Stimpfel M Abstract Small stem cells with diameters of up to 5 μm previously isolated from adult human ovaries indicated pluripotency and germinal lineage, especially primordial germ cells, and developed into primitive oocyte-like cells in vitro. Here, we show that a comparable population of small stem cells can be found in the ovarian tissue of women with borderline ovarian cancer, which, in contrast to small stem cells in "healthy" ovaries, formed spontaneous tumour-like structures and expressed some markers related to pluripotency and germinal lineage. The gene expression profile of these small putative cancer stem cells differed from similar cells sorted from "healthy" ovaries by 132 upregulated and 97 downregulated genes, including some important forkhead box and homeobox genes related to transcription regulation, developmental processes, embryogenesis, and ovarian cancer. These putative cancer stem cells are suggested to be a novel population of ovarian tumour-initiating cells in humans. PMID: 27703207 [PubMed - indexed for ...

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