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[Correspondence] Isoniazid-resistant tuberculosis treatment with first-line drugs

We read with interest the systematic review and meta-analysis by Medea Gegia and colleagues1 of use of first-line drugs for isoniazid-monoresistant tuberculosis. Among the main findings, this study revealed that 11% of new patients who received the first-line WHO standard regimen had treatment failure. On the basis of these observations, the authors suggest that standardised empirical treatment of new cases could be contributing substantially to the multidrug-resistant tuberculosis epidemic. However, the authors do not question the reliability of the initial bacteriological diagnosis that was made for these patients, which supported the clinical decision to initiate standardised first-line treatment.

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Tags: infectiology, medical, MEDICINE
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