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[Correspondence] Duration of surgical antibiotic prophylaxis in patients with asymptomatic bacteriuria – Authors' reply

We agree with Jorge Andres Ramos and colleagues on the important role of appropriate surgical antibiotic prophylaxis (SAP). WHO guidelines1 recommend SAP within 120 min before surgery without any prolongation after completion of the procedure. Timing of appropriate SAP before surgery should be guided also by the pharmacological properties (half-life and protein binding) of the antibiotic. In addition, the need for redosing during surgery should take into account the patient's pathophysiological conditions affecting drug disposition once injected (eg, renal or liver impairment, massive blood loss, and fluid replacement or transfusions), together with total duration of the intervention.

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Tags: infectiology, medical, MEDICINE
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